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Research
Graduate student researcher (who is also a chronic pelvic pain patient) seeks study participants for a pilot study on positive emotions and spirituality among female chronic pelvic pain patients. The criteria for being enrolled in the pilot study are:
1- At least two months since clinical diagnosis of chronic pelvic pain
and
2- English speaking
Pilot study participants will be asked to fill out three surveys, which will take approximately 15 minutes in total to complete. Amazon website certificates of $10 will be offered to study participants as compensation for their time.
To enroll in this pilot study, contact Erica Hamilton at: ericahamilt@gmail.com or 1-415-690-5818.
If you are interested in receiving free e-mail occasional updates when new items are added to the website, subscribe to our free newsletter using the button on this page.
Pain and Gender - BBC radio 4 Women's Hour - listen to the programme
Differences in the way that men and women express pain- research from Vienna University
Chronic Pelvic Pain in Women
IThe following articles relate to the prevalence, incidence, diagnosis and referral for women with chronic pelvic pain in the UK:
The community prevalence of chronic pelvic pain in women and associated illness behaviour - click here Zondervan KT, Yudkin PL, Vessey MP, et al
Br J Gen Pract 2001; 51: 541-547
Prevalence and incidence of chronic pelvic pain in primary care: evidence from a national general practice database - click here
Krina T. Zondervan, Patricia L. Yudkin, Martin P. Vessey, Martin G. Dawes, David H. Barlow, Stephen H. Kennedy
BJOG Nov 1999, vol 106,pp 1149-1155 The definitive version of this article is available at blackwell synergy.
Patterns of diagnosis and referral in women consulting for pelvic pain in UK primary care - click here Krina T. Zondervan, Patricia L. Yudkin, Martin P. Vessey, Martin G. Dawes, David H. Barlow, Stephen H. Kennedy
BJOG Nov 1999, vol 106,pp 1156-1161 The definitive version of this article is available at blackwell synergy.
Health services for women with chronic pelvic pain- Stones RW, Price C J R Soc Med 2002; 95:531-535
Information about women referred to British pain clinics for chronic pelvic pain is available from the Pain Society's PACS database. Figure 3 shows a comparison of treatments provided to all patients and to women with pelvic pain. Brief Pain Inventory pain scores were similar to those in the general pain clinic population but the range of treatments offered to women with chronic pelvic pain was very different.
Click here
Interventions for treating chronic pelvic pain in women:
Stones RW, Cheong YC, Howard FM
Cochrane - abstract
Interventions for treating chronic pelvic pain in women:
Cochrane - Full Systematic Review article
Authors as above
Chronic Pelvic Pain in Women and Men
Pelvic Pain in Women and Men: recent findings
Ness TJ
Current Opinion in Anaesthesiology 2005 Oct
Abstract:http://www.ncbi.nlm.nih.gov
Adhesions
Barrier agents for adhesion prevention after gynaecological surgery (ovarian/ tubal surgery )
Cochrane database of systematic reviews 2008
Fluid and pharmacological agents for adhesion prevention after gynaecological surgery
Cochrane database of systematic reviews 2006 Summary
The effectiveness of a single intraperitoneal infusion of a neurokinin-1 receptor antagonist in reducing postoperative adhesion formation is time dependent
Cohen PA, Aarons CB, Gower AC et al
Surgery 2007 Mar; 141(3):368-75
Abstract: http://www.ncbi.nlm.nih.gov
Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity
Aarons CB et al
Ann Surg 2007 Feb;245(2):176-84
Abstract:
A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity
K. Reed et al
Proc Natl Acad Sci USA 2004 June 15;101(24):9115-9120
Full text article
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=428482
Immunomodulatory properties of substance P
The gastrointestinal system as a model
Hon Wai Koon and Charalabos Pothoulakis
Abstract:
http://www.annalsnyas.org/cgi/content/abstract/1088/1/23
Bladder Pain Syndrome (BPS) /Interstitial Cystitis(IC)
Diagnostic Criteria, Classification, and Nomenclature for Painful Bladder Syndrome/Interstitial Cystitis: An ESSIC Proposal
van de Merve J et al
Eur Urol 2008 Jan
Pubmed abstract
Intravesical treatments for painful bladder syndrome.
Dawson TE, Jamison J. 2007
Cochrane Database Syst Rev. 2007 Oct 17; (4): CD006113
Chronic Pelvic Pain in Men
Chronic Prostatitis/Chronic Pelvic Pain Syndrome
A study on the prevalence of prostatitis-like symptoms in a managed care population in the Pacific North West USA was published in the Journal of Urology in 2006. This population based study indicates that approximately 1 in 9 men have prostatitis like symptoms.
The summary of this article can be accessed here : http://cat.inist.fr/?aModele=afficheN&cpsidt=17957515
A recent article indicating the neurological implications of chronic pelvic pain in men was published in BMC Urology in 2005.
Toe spreading ability in men with chronic pelvic pain syndrome
Ugur Yilmaz, Ivan Rothman, Marcia A Ciol , Claire C Yang and Richard E Berger
BMC Urology 2005, 5:11 doi:10.1186/1471-2490-5-11
The full article can be accessed below:
http://www.biomedcentral.com/1471-2490/5/11
The Pubmed abstract of the above article can be accessed below:
Pain sensitization in male chronic pelvic pain syndrome:
why are symptoms so difficult to treat ?
J Urol Sep 2003; 170(3):823-826 discussion 826-827
Yang CC, Lee JC, Kromm BG, Ciol MA, Berger RE
The Pubmed abstract of this article is :
Predictors of quality of life and pain in chronic prostatitis/chronic pelvic pain syndrome: findings from the National Institutes of Health Chronic Prostatitis Cohort Study
Tripp DA, Curtis Nickel J, Landis JR, Wang YL, Knauss JS, CPCRN Study Group
BJU Int 2004 Dec:94(9): 1279-82
The Pubmed abstract of this article:
Acupuncture for chronic prostatitis/chronic pelvic pain syndrome
Chen RC, Nickel JC
Curr Urol Rep 2004 Aug;5(4):305-8
The Pubmed abstract of this article:
Acupuncture ameliorates symptoms in men with chronic prostatitis/chronic pelvic pain syndrome
Chen R, Nickel JC
Urology 2003 Jun;61(6):1156-9; discussion 1159
The Pubmed abstract of this article:
The impact of chronic prostatitis/chronic pelvic pain syndrome on patients
McNaughton Collins M
World J Urol 2003 Jun;21(2):86-9
The Pubmed abstract of this article:
Healthcare use and costs of primary and secondary care patients with prostatitis.
Turner JA et al
Urology 2004 Jun
Primary care and urology patients with the male pelvic pain syndrome: symptoms and quality of life
Turner JA et al
J Urol 2002 Apr
Prognosis of patients with new prostatitis/pelvic pain syndrome episodes
Turner JA et al
J Urology. 2004 Aug
Pubmed abstract:
Men with pelvic pain: perceived helpfulness of medical and self-management strategies
Turner JA et al
Clin J Pain 2006 Jan
Endometriosis
High density of small nerve fibres in the functional layer of of the endometrium in women with endometriosis
Tokushige N, Markham R, Russell P, Fraser IS
Human Reproduction 2006 Mar
Pubmed abstract
Nerve fibres in peritoneal endometriosis
Tokushige N, Markham R, Russell P, Fraser IS
Human Reproduction 2006 Nov
Pubmed abstract
Growth-associated protein 43-positive sensory nerve fibers accompanied by immature vessels are located in or near peritoneal endometriotic lesions
Mechsner S et al
Fertil Steril 2007 Sep
Pubmed abstract
Different types of small nerve fibres in eutopic endometriumand myometrium in women with endometriosis
Tokuschige N et al
Fertil Steril 2007 Oct
Pubmed abstract
Effects of hormonal treatment on nerve fibres in endometrium and myometrium in women with endometriosis
Tokuschige N et al
Fertil Steril 2007 Nov
Pubmed abstract
A pilot study to evaluate the relative efficacy of endometrial biopsy and full curettage in making a diagnosis of endometriosisby the detection of endometrial nerve fibres
Al-JefoutM et al
Am J Obstet Gynecol 2007 Dec
Pubmed abstract
Irritable Bowel Syndrome(IBS)
Impact of irritable bowel syndrome on quality of life and resource use in the United States and the United Kingdom
Hahn BA, Yan S, Strassels S
Digestion 1999 Jan- Feb
Pubmed abstract :
The epidemiology of hysterectomy and irritable bowel syndrome un a UK population
Kennedy TM, Jones RH
Int J Clin Pract 2000 Dec
Pubmed abstract:
Health-related quality of life and cost impact of irritable bowel syndrome in a UK primary care setting.
Akehurst RL, Brazier JE
Pharmacoeconomics 2002
Pubmed abstract:
Burden of illness in irritable bowel syndrome comparing Rome 1 and Rome 11 criteria.
Badia X, Mearin F
Phamacoeconomics 2002
Pubmed abstract:
Health-related quality of life associated with irritable bowel syndrome: comparison with other diseases
Frank L et al
Clin Ther 2002 Apr
Pubmed abstract:
Natural Killer Cell Function and Psychological Distress in Women with and without Irritable Bowel Syndrome
Motzer SA, Jarrett M, Heitkemper M, Tsuji BA
Biological Research for Nursing 2002 vol 4
Abstract : http://brn.sagepub.com/cgi/content/abstract/4/1/31
Impact of irritable bowel syndrome (IBS) on health-related quality of life (HRQOL)
Amouretti M et al
Gastroenterol Clin Biol 2006 Feb
Pubmed abstract:
Irritable Bowel Syndrome
Spinelli A
Clin Drug Investig 2007
Pubmed abstract:
Functional Abdominal Pain Syndrome
Functional Abdominal Pain Syndrome
Ray E Clouse, Emeran A Mayer, Qasim Aziz, Douglas A. Drossman et al
Gastroenterology 2006
Pubmed abstract: http://www.ncbi.nlm.nih.gov
Functional Abdominal Pain Syndrome
Drossman DA
Clin Gastroenterol Hepatol 2004 May
Pubmed abstract:
Functional bowel disorders and functional abdominal pain
WG Thompson, GF Longstreth, DA Drossman et al
Gut 1999
Abstract : http://gut.bmj.com/cgi/content/abstract/45/suppl_2/II43
There are recent several articles from Gastroenterology 2006- April on the above topics and an article entitled "Gender, Age, Society, Culture, and the Patient's Perspective in the Functional Gastrointestinal Disorders" Lin Chang et al at http://www.romecriteria.org
PAIN MECHANISMS
There are several articles about Pain mechanisms on the Wellcome Trust website:
Sensing damage
www.wellcome.ac.uk/en/pain/microsite/science1.html
Mapping pain in the brain
www.wellcome.ac.uk/en/pain/microsite/science2.html
Visceral pain
www.wellcome.ac.uk/en/pain/microsite/science3.html
Pain hypersensitivity
www.wellcome.ac.uk/en/pain/microsite/science4.html
The website for the Pain Imaging Neuroscience Group is: www.fmrib.ox.ac.uk/pain
A randomized, placebo-controlled, crossover design to study the effect of amitriptyline on pain-related brain activation in patients with IBS using fMRI emphasizes the significant role of stress in IBS. Morgan V et al “Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome.“ Gut 2005
An fMRI study of female patients with fibromyalgia supported the well known association between clinical pain and severity of depressive symptoms. The study emphasises the usefulness of fMRI in separating the different components of the pain experience and complementing the patients report of pain. Giesecke T et al “The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort. Arthritis Rheum 2005;52:1577-1584
The Pain Sciences Research Unit at the University of Queensland Australia has a number of research projects including:
- Investigating the mechanisms involved in the development of chronic musculoskeletal pain conditions
- Investigation of neuropathic components of musculoskeletal pain conditions
- Mechanisms of physiotherapeutic interventions for chronic musculoskeletal pain conditions
- www.shrs.uq.edu.au/physio/research/pain_sciences.html
PELVIC INFLAMMATORY DISEASE
Lower Quality of Life Among Women With Chronic Pelvic Pain After Pelvic Inflammatory Disease- Haggerty CL et al, Obstetrics & Gynaecology Nov 2003;102:934-939
This article concludes that chronic pelvic pain after PID is associated with reduced physical and mental health.
Newest Approaches to treatment of Pelvic Inflammatory Disease: a review of recent randomized controlled trials.
Haggerty CL, Ness RB
Clin Infect Dis 2007
Pubmed abstract: http://www.ncbi.nlm.nih.gov
Vulval Conditions
Vulvodynia: Diagnosis and Management - March 1, 2006 -- American Family Physician
Chronic vulvar purpura:persistent pigmented purpuric dermatitis (lichen aureus) of the vulva or plasma cell (Zoon's ) vulvitis ? Qing Liet al, Journal of Cutaneous Pathology 2003 30 ( 9), 572-576
Blackwell Synergy - J Cutan Pathol, Volume 30 Issue 9 Page 572-576, October 2003 (Article Abstract)
Vulvitis circumscripta plasmacelluraris (Zoon's vulvitis) associated withautoimmune polyglandular endocrine failure. SalopekTG, Simonoski K, Br J Dermato. 1996 Dec;135 (6): 991-4
Blackwell Synergy - Br J Dermatol, Volume 135 Issue 6 Page 991-994, December 1996 (Article Abstract)
